HORDB

ID: hor000972
Uniprot ID: P01356
Protein name: Cholecystokinin-58
Gene name: CCK
Organism: Sus scrofa (Pig)
Family: Gastrin/cholecystokinin family
Source: animal
Expression: Synthesized in both cerebral cortex and duodenal mucosa.
Disease: NA
Comments: NA
Taxonomy: Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0051428 peptide hormone receptor binding
GO BP: GO:0001764 neuron migration; GO:0007165 signal transduction; GO:0007409 axonogenesis; GO:0007586 digestion; GO:0042755 eating behavior
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030424 axon

Sequence: AVQKVDGESRAHLGALLARYIQQARKAPSGRVSMIKNLQSLDPSHRISDRDYMGWMDF
Length: 58
Propeptide: MNGGLCLCVLMAVLAAGTLAQPVPPADSAVPGAQEEEAHRRQLRAVQKVDGESRAHLGALLARYIQQARKAPSGRVSMIKNLQSLDPSHRISDRDYMGWMDFGRRSAEEYEYTS
Signal peptide: MNGGLCLCVLMAVLAAGTLA
Modification: T52 Sulfotyrosine;T58 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut.Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Mechanism: NA
Cross BBB: NA
Target: CCKBR, CCKAR
Target Unid: A0A287A2K5, I3LFK5
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000972_AF2.pdb

hor000972_ESM.pdb

Mass:	758941	Formula:	C285H459N89O84S3
Absent amino acids:	CT	Common amino acids:	ARSDL
pI:	10.31	Basic residues:	11
Polar residues:	13	Hydrophobic residues:	19
Hydrophobicity:	-55.69	Boman Index:	-13692
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	79.14
Instability Index:	4308.79	Extinction Coefficient cystines:	8480
Absorbance 280nm:	148.77